The genetic research centre “Med-Diagnostics” was established in 2020. The team is stuffed by the successful scientific group of biologists, bioinformatics and doctors working in the US and Europe. The arrival of international standard molecular genetic researches is the goal of our team.
The goal of our team is to introduce studies based on molecular-genetic methods of international standard in Georgia, which will give Georgian doctors exact information needed for the correct diagnosis and treatment of the patient.
We currently have more than 120 employees who have been trained at leading international research institutes in the United States and England. It is noteworthy that, our staff has undergone special training in the relevant field directions at Thermo Fisher Scientific Europe Headquarters.
Today Med-Diagnostics offers patients molecular genetic studies: oncohematology, clinical oncology, Reproductology, obstetrics-gynecology, infectious diseases, pharmacogenomics, preventive medicine, pediatrics-neonatology and endocrinology.
The goal of the Molecular Research Center Med-Diagnostics is to introduce the achievements of diagnostic medicine and international standards in Georgia.
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Gregor Mendel, “The father of Genetics” stands in the beginning of number of discoveries. He was the first one to have hypothesis, that Genetic Characteristics do transfer from a Generation to another. Mendel created terminological units such as “Recessive” and “Dominant” which are so well-known in modern society.
Friedrich Miescher isolated nucleus structure, which contains molecule of DNA
Laureate of Nobel Prize, German Biochemist Albrecht Kossel, was first to give the name to DNA as nucleic acid and he also defined 5 nitrogenous bases: Adenine(A), Cytosine ( C ) , Guanine(G), Thymin(T) (Uracil (U) in RNA)
Soon after Kossel’s findings, Walther Flemming discovered mitosis in 1882 and became the first biologist, who conducted systematic study of chromosome division.
Theodor Boveri and Walter Sutton
Theodor Boveri and Walter Sutton had been working independently on the theory which later became known as Boveri-Sutton Chromosome Theory or Chromosomal Theory of Inheritance. Their conclusions are fundamental in understanding how chromosomes carry the genetic material and information which are transferred from one generation to another.
Sir Archibald Edward Garrod
Sir Archibald Edward Garrod published first conclusions in 1902, which were based on the studies conducted about recessive heredity in humans.
Oswald Avery was first who named DNA as carrier of information carrier.
Erwin Chargaff discovered, that DNA is responsible for heredity and it is different in between species. His discoveries which are known by “Chargaff’s rules” confirmed, that units of guanine and cytosine, as well as adenine and thymin are alike in double stranded DNA and differs in between the species.
Barbara MacKinnon discovered the mobility of genes by the end of 1940s, in particular she found “jumping genes” phenomenon.
Rosalind Franklin had been working in X-ray crystallography and she managed to obtain diffractive X-ray photo material. Her pictures displayed spiral form of DNA, which Watson and Crick confirmed after 2 years.
Watson and Crick
Watson and Crick confirmed the spatial configuration of DNA and published the work about DNA’s stranded helix structure.
The Human Genome project
The Human Genome project was started in 1990, it lasted for 15 years and aimed to identify all of the DNA sequences.
Each DNA contains 100 millions of nucleotides, each human being is made of 6billions of nucleotides. Each cell contains 23 pairs of chromosomes, which hold DNA molecule. The unity of chromosome creates Genome. Genomic is the part of Genetics, which addresses structure of Genome and it’s main principles of work.
On the modern step of development of Medical Field, personal, precise medicine has obtained the most crucial meaning. Personalised medicine regards creating particular groups of patients, for whom medical service, intervention and medications are chosen appropriate to their individual needs and demands, regarding individual sensitivity to each medication, as well as patient’s isolated risks of developing different disease.
The importance of this particular approach has increased with new number of molecular-biologic diagnostic tests and bioinformatic methods and for the most parts, with the development of genomic field. In particular, methods of genomic made it possible to determine factors, which contribute to developing the disease, subsequently calculating molecular basis of risks for individual patients.
Each individual is characterised by unique variation of Genome, which on it’s own doesn’t affect human health, but in certain environmental factos and particular behavioural norms, genome acquires critical importance. Team of Med-Diagnostics aims to evolve and increase the number of hardware bases as well as material-technical bases and diagnostics of other different genetic disease.